GET YOUR METABOLISM MOVING.
This is the little compound researchers reach for when the study is about fat, energy, and how cells actually burn fuel. Here’s what it is, how it’s studied, and how researchers handle it in the lab.
Pep Hub products are for laboratory research use only.
Primary Benefits
- Blocks the NNMT enzyme to support fat loss and energy production
- Raises NAD⁺ levels to help mitochondrial function
- May support cognitive function and neuroprotection
- Promotes better insulin sensitivity and glucose regulation
- Possible application in research on obesity, metabolic dysfunction, and longevity
Mechanism of Action
5-Amino-1MQ is a small molecule peptide that inhibits NNMT (nicotinamide N-methyltransferase). That enzyme is overexpressed in fat cells and tied to impaired energy metabolism.
Block NNMT, and you boost NAD⁺ availability. That helps switch fat-burning genes “on” while turning fat storage down. It also supports metabolic function right at the cellular level.
Dosing & Protocol
Subcutaneous (SQ) Injection (preferred):
- Reconstitution:
- 5 mg vial → 3.0 mL bacteriostatic water
- Daily Dose:
- 160–250 mcg (10–15 units)
- Cycle: 5–7 days per week, 6–12 weeks on, then 2–4 weeks off
- Timing: Take in the morning on an empty stomach, at least 30 minutes before eating.
Potential Side Effects
- Mild irritation at the injection site (rare)
- Slight jitteriness or overstimulation in sensitive individuals
- Increased energy or thermogenesis — which may affect sleep if taken too late in the day
- Rarely: mild headaches or nausea at higher doses
Common Stacks
- With BPC-157 and TB-500: For enhanced metabolic, immune and anti-inflammatory support
- With AOD-9604: For enhanced fat metabolism and lipolysis
- With CJC-1295 / Ipamorelin: For synergistic metabolic and GH support
- With MK-677: For additional appetite stimulation and anabolic effect (if desired)
Notes
- Morning is best — this one has an energizing effect.
- Injection is subcutaneous into the lower abdomen.
- Store in the refrigerator after reconstitution and use within 45 days unless the product label or protocol says otherwise.
- If you develop the flu, a significant infection, or any acute illness where your body’s ATP production needs to prioritize immune function, pause 5-Amino-1MQ and resume only once you have recovered.
Want to check a lot? Use Check Your Vial, and find the full lab reports in The Receipts.
Disclaimer: The information provided in this article is for educational and informational purposes only and is not intended as medical advice. These statements have not been evaluated by the FDA or Health Canada. Peptides and other compounds discussed are intended for research purposes only and are not approved for human consumption unless prescribed by a licensed medical professional. Always consult your healthcare provider before starting any new protocol, supplement, or treatment.
Still have questions?
Reach out through Pep Hub’s Help Center. Live support is on WhatsApp, with agents available 10am–10pm.