Prime Metabolic — 12-Week Cycle Dosing Guide

Retatrutide + BPC-157 + TB-500 + 5-Amino-1MQ. The long game: twelve weeks of repair while you cut. GET SNATCHED — and stay that way.

Why People Choose the Prime Metabolic 12-Week Cycle

Promotes meaningful, sustained weight loss with appetite control (triple-agonist activity)
Improves blood sugar control and insulin sensitivity to support healthier glucose dynamics
Supports cellular energy and metabolic efficiency via NNMT inhibition (pairs well with weight-loss stacks)
Accelerates soft-tissue healing and recovery (tendon, ligament, and muscle) while reducing inflammation
Repairs and protects the gut lining to support GI comfort and resilience
Enhances joint mobility and flexibility to keep you moving during training and recovery
Supports healthy blood flow and angiogenesis in healing tissues for better repair
Contributes to overall cardio-metabolic health alongside lifestyle changes
Synergistic stack for “repair while you cut” — pairing tissue regeneration with fat-loss support
Resets metabolic balance for sustainable fat loss and recovery

What’s in Your Prime Metabolic 12-Week Cycle Kit

Peptides

2 × Retatrutide (10 mg)
4 × BPC-157 (5 mg)
4 × TB-500 (5 mg)
3 × 5-Amino-1MQ (5 mg)

Supplies

4 × 10 mL Bacteriostatic Water (BAC Water)
75 × 1 mL insulin syringes (30–31G, 6–8 mm)
14 × 3 mL reconstitution syringes
14 × syringe tips (vial vents)
100 × alcohol pads
Step-by-step dosing protocol

Peptide Storage

Storage for Lyophilized (Freeze-Dried) Peptides (Powder Form)

After arrival: store dry/lyophilized vials in the refrigerator (2 to 8 °C) for up to 6 months, or in the freezer (−20 °C or colder) for up to 2 years.
Keep vials tightly capped, dry, dark, and protected from moisture.
Avoid repeated freezing and thawing.

Storage for Reconstituted Peptides (Mixed with BAC Water)

Refrigerate at 2 to 8 °C.
Do not freeze.
Use within 45 days unless the product label/protocol says otherwise.
Label vials with date and concentration.

Reconstitution (Mixing)

For easy calculating and to fit the full 12-week cycle:
– Retatrutide 10 mg: add 2.0 mL BAC Water
– BPC-157 5 mg: add 2.5 mL BAC Water
– TB-500 5 mg: add 2.5 mL BAC Water
– 5-Amino-1MQ 5 mg: add 3.0 mL BAC Water

Gently swirl or roll after adding BAC Water — do not shake.

Injection (Dosing)

Timing: Inject once each morning on an empty stomach, at least 30 minutes before food.

Frequency

Take daily peptides (BPC-157, TB-500, 5-Amino-1MQ) Monday to Friday.
Weekends off for BPC-157, TB-500, and 5-Amino-1MQ (5 days on / 2 days off).
Retatrutide is once weekly on your chosen day (keep the same day/time each week).

Injection method: Subcutaneous (SQ).
Syringe: Insulin type (1 mL, 30–31G, 6–8 mm).

Combine in the same syringe Monday to Friday

Draw from each vial into one syringe:
– BPC-157: 15 units (300 mcg)
– TB-500: 15 units (300 mcg)
– 5-Amino-1MQ: 12 units (200 mcg)

Total each weekday: 42 units.

Take in its own syringe once per week

Retatrutide: inject once weekly on your chosen day (e.g., every Sunday).
Weeks 1–4: 20 units (1 mg) per week
Weeks 5–12: Increase to 40 units (2 mg) per week
This research protocol tops out at 2 mg per week in this cycle.
Take on the same day and time each week for stable blood levels.

Weekends

Skip BPC-157, TB-500, and 5-Amino-1MQ.
Retatrutide is once weekly on your chosen day.

Cycle Length

Total: 12 weeks
BPC-157, TB-500, 5-Amino-1MQ: 5 days on / 2 days off
Retatrutide: once weekly

Peptide Intake Overview

BPC-157: 300 mcg × 60 weekdays = 18,000 mcg (18 mg)
TB-500: 300 mcg × 60 weekdays = 18,000 mcg (18 mg)
5-Amino-1MQ: 200 mcg × 60 weekdays = 12,000 mcg (12 mg)
Retatrutide: 1 mg × 4 weeks + 2 mg × 8 weeks = 20 mg total

Any supply left at the end of the cycle is custom math: use the dosage calculator in the Help Center to work out the remaining doses for your vial size and schedule.

Inject Safely

Preferred sites (subcutaneous)

Abdomen, at least 5 cm from navel
Outer thigh
Upper-outer arm (rotate 1 to 2 cm from last site)

Quick steps

Clean the vial top with an alcohol pad
Draw dose(s) into syringe
Clean the location of injection with an alcohol pad
Pinch and lift skin at the location of injection
Inject slowly at a 45° angle just under the skin (SQ)
Apply gentle pressure with an alcohol pad for 30 seconds
Dispose of the syringe in a sharps container

Notes

Preferred sites: fatty part of abdomen (at least 5 cm from navel), outer thigh, or upper-outer arm.
Rotate injection site (1 to 2 cm).
Wipe skin and let alcohol dry before injection.
If you miss a dose, resume at the next scheduled time. Do not double up.
Maintain hydration, movement, and good sleep.
Keep everything labeled and store safely.
Seek medical care urgently if you experience: spreading redness and warmth, severe swelling, fever, pus, red streaks, or signs of allergy (hives, facial swelling, trouble breathing).
If you develop the flu, a significant infection, or any acute illness where your body’s ATP production needs to prioritize immune function, pause 5-Amino-1MQ and resume only once you have recovered.
Do not use peptides if pregnant or breastfeeding.

Possible Side Effects (Common & Mild)

Small bruise
Brief redness or itch at site
Occasional nausea or fatigue

Peptide Measurement Guide

mg: milligram; measures the total amount of peptide in a vial
mcg: microgram; measures an injection dose (1 mg = 1,000 mcg)
mL: milliliter; measures the volume of BAC water for reconstitution
unit: insulin-syringe marking for dose calculation (1 mL = 100 units on a standard insulin syringe)

Need Help Calculating Your Dose?

Our dosage calculator in the Help Center makes it easy to prepare accurate peptide doses.

References

Jastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity – A Phase 2 Trial. N Engl J Med. 2023;389(6):514-526. PubMed
Rosenstock J, et al. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. Lancet. 2023;402(10401):529-544. PubMed
Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. PubMed
Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. PubMed
Sikiric P, et al. Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing. Curr Pharm Des. 2018;24(18):1990-2001. PubMed
Goldstein AL, Kleinman HK. Advances in the basic and clinical applications of thymosin β4. Expert Opin Biol Ther. 2015;15 Suppl 1:S139-S145. PubMed

Disclaimer

This guide is for educational purposes only and is not medical advice. Peptides are research compounds and are not approved for human use unless prescribed by a medical practitioner. Always consult your medical practitioner before starting any protocol.

Still have questions?

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